Dok2 - Wikipedia

Dok2 - 维基百科，自由的百科全书

Dok2. 李埈京 （韓語： 이준경 ，1990年3月28日 — ）是一位韓國饒舌歌手及音樂製作人，他以藝名 DOK2 （韓語： 도끼 ）為人熟知。. 同時，他也是韓國 嘻哈 音樂公司 Illionaire Records 的CEO [1] 。. 在2011年與The Quiett一起創辦經紀公司1llionaire Records。. 2016年成立了 ...

DOK1 and DOK2 regulate CD8 T cell signaling and memory ... - Nature

Dok1 and Dok2 invalidation improves TCR signaling in primed CD8 + T cells. We, then, sought to explore the role of DOK1 and DOK2 invalidation in TCR signaling. We used two doses (5 and 1 μg/mL ...

Korean rapper Dok2 releases his new track 'Culture' after a 2-year ...

Dok2 announced his comeback by releasing a new track, 'Culture,' on April 25. As soon as this happened, the comments section of his Instagram post announcing his return blew up with a lot of Korean rappers welcoming him back. The link to this photo or video may be broken, or the post may have been removed. Dok2 was born in the United States ...

Dok2 - 维基百科，自由的百科全书

Dok2. 李埈京 （韩语： 이준경 ，1990年3月28日 — ）是一位韩国饶舌歌手及音乐制作人，他以艺名 DOK2 （韩语： 도끼 ）为人熟知。. 同时，他也是韩国 嘻哈 音乐公司 Illionaire Records 的CEO [1] 。. 在2011年与The Quiett一起创办经纪公司1llionaire Records。. 2016年成立了 ...

Rapper Dok2 Reveals Staggering Earnings And Future Goals

The July 13 episode of MBC's "Radio Star" features rapper Dok2, actor Kim Bo Sung, former U-KISS member Dongho, and model Joo Woo Jae for the show's "My Life, Turn~Up!" special. On the ...

Dok2 Announces He's Fulfilling Childhood Dream Of Moving To ... - Soompi

Dok2 will be moving abroad. After previously informing fans that he moved out of his hotel penthouse, Dok2 revealed that his new home will be located in the United States. The rapper recently ...

Dok2 profile, age & facts (2024 updated) | kpopping

Dok2 (도끼), born Lee Jun-kyung (이준경) is a South Korean rapper who debuted independently in 2008. He's the founder of ILLIONAIRE Records along with The Quiett. 143 Entertainment: Feb 21, 2022-present . Last Kings Records: Apr 15, 2021-present . Illionaire Records: Jan 1, 2011-Feb 6, 2020 .

DOK2 Profile and Facts (Updated!) - Kpop Profiles

Rap Name: DOK2 (pronounced as Dokki) Birth Name: Lee Joon-Kyung (이준경) Birthday: March 28, 1990 Zodiac Sign: Aries Height: 161 cm (5'3″) Blood Type: B Instagram: dok2gonzo Twitter: notoriousgonzo SoundCloud: thameditatah DOK2 Facts: - His mother is Korean, and his father is Spanish and Filipino. - He was the co-founder of 1llionaire Records. - In 2014, people started saying ...

Introduction to DOK2 and its Potential Role in Cancer - PMC

DOK2 and cell fusion and proliferation. Kajikawa et al. demonstrated that DOK2 is expressed in both macrophages and monocytes in blood, with DOK2 regulating multiple signaling pathways via negative feedback which affects osteoclast proliferation. In a mouse model in which the DOK1 and DOK2 genes had been knocked out, animals were found to have larger numbers of osteoclasts and were more likely ...

DOK2 Has Prognostic and Immunologic Significance in Adults With Acute ...

Supplementary Figure S3: DOK2 expression levels in pan-cancer analysis.(A) Boxplots for DOK2 expression in pan-cancer compared with healthy controls.(B) The mRNA expression levels of DOK2 within diverse cancer cell lines from the CCLE.(C) The DNA methylation levels of DOK2 in different cancer cell lines from the CCLE. The interpretation of cancer abbreviations can be obtained from the TCGA ...

Introduction to DOK2 and its potential role in cancer - PubMed

Dok2 protein, mouse. Phosphoproteins. Cancer is a complex, multifactorial disease that modern medicine ultimately aims to overcome. Downstream of tyrosine kinase 2 (DOK2) is a well-known tumor suppressor gene, and a member of the downstream protein DOK family of tyrosine kinases. Through a search of original literature indexed in PubMed ….

Dok1 and Dok2 proteins regulate natural killer cell development and ...

Dok1 and Dok2 proteins are substrates of protein tyrosine kinases in NK cells. Dok family members are involved in immune cell signaling; however, their expression in NK cells has not been investigated (Mashima et al, 2009). DOK1 and especially DOK2 transcripts are expressed in both human and mouse NK cells. Other DOK genes appear not to be expressed in NK cells (Supplementary Fig S1).

Dok2 Lyrics, Songs, and Albums | Genius

쇼미더머니 (Show Me The Money) Lotto. VERNON (버논) 도박 (Life Is a Gamble) Ja Mezz, YNL. Woodie Gochild & Junoflo. Show all songs by Dok2. Popular Dok2 albums. THE CORE TAPE, Vol. 1.

DOK2 Has Prognostic and Immunologic Significance in Adults ... - PubMed

Background: The role of downstream tyrosine kinase 2 (DOK2), a major member of the DOK family, remains poorly defined in acute myeloid leukemia (AML). Herein, we investigated the expression levels, clinical outcomes, and biological functions of DOK2 in patients with AML. Methods: Datasets were obtained from the Cancer Genome Atlas (TCGA) database for transcriptomic and clinical information.

DOK2 Gene - GeneCards | DOK2 Protein | DOK2 Antibody

DOK2 (Docking Protein 2) is a Protein Coding gene. Diseases associated with DOK2 include Histiocytic And Dendritic Cell Cancer.Among its related pathways are Immune response IL-23 signaling pathway and Nervous system development.Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity, downstream of receptor and transmembrane receptor protein tyrosine ...

A new role for Dok | Nature Reviews Cancer

To investigate further, the authors examined tumour progression in Dok1-, Dok2- or Dok3-knockout mice, as well as in double knockouts (DKOs) and triple knockouts (TKOs). They found that although ...

Frontiers | DOK2 Has Prognostic and Immunologic Significance in Adults ...

Figure 1.DOK2 mRNA expression levels in AML patients. (A) The transcription levels of DOK2 from the TCGA.(B) Transcription levels of DOK2 in GSE9476.(C) Transcription levels of DOK2 in GSE30029.(D) The ROC curve for DOK2 in the TCGA AML vs. normal.(E-J) Association of DOK2 expression with age, WBC count, risk level, recurred/progressed status, FAB classification (M0, M1, M2, M4, M5), and APL ...

Expression and significance of DOK2 in colorectal cancer - PMC

Immunohistochemical staining. DOK2 was detected by immunohistochemical staining, as described previously ().Briefly, following deparaffinization in xylene and dehydration in graded ethanol solutions, 3.0-μm sections of colorectal cancer tissue and normal colorectal mucosa were heated at 121°C for 20 min in ethylenediaminetetraacetic acid-Tris buffer (pH 9.0) for antigen retrieval.

The Tek/Tie2 receptor signals through a novel Dok-related docking ...

Using this approach, we have identified a novel docking molecule called Dok-R, which has sequence and structural homology to p62dok and IRS-3. Mapping of the phosphotyrosine-interaction domain within Dok-R shows that Dok-R interacts with Tek through a PTB domain. Dok-R is coexpressed with Tek in a number of endothelial cell lines.

Comprehensive analysis of DOK family genes expression, immune ...

DOK2 and DOK3 are similar to DOK1 and act as tumor suppressor genes in most tumors, including lung cancer, gastric cancer, colorectal cancer, and acute myeloid leukemia [26], [11], [27]. Here, we found that DOK2 expression indicates an improved prognosis in HNSC, LUAD, SARC, SKCM, and UCEC, but a poor prognosis in GBM, LAML, and UVM.

DOK4 and DOK5: new dok-related genes expressed in human T cells

In group A, only DOK1 and DOK2 genes are expressed in T cells, consistent with data published in mouse tissues. 15 In group B, expression of DOK4 or DOK5 gene can be detected in human peripheral ...

DOK2 Inhibits EGFR -Mutated Lung Adenocarcinoma - PLOS

Somatic mutations in the EGFR proto-oncogene occur in ~15% of human lung adenocarcinomas and the importance of EGFR mutations for the initiation and maintenance of lung cancer is well established from mouse models and cancer therapy trials in human lung cancer patients. Recently, we identified DOK2 as a lung adenocarcinoma tumor suppressor gene. Here we show that genomic loss of DOK2 is ...